2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1164
    Bromopride 4093-35-0 99.87%
    Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist. Bromopride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting).
    Bromopride
  • HY-B1185
    Beclamide 501-68-8 98.86%
    Beclamide is an active molecule with anticonvulsant activity, used as an anticonvulsant drug.
    Beclamide
  • HY-B1475
    Anisotropine bromide 80-50-2 ≥98.0%
    Anisotropine (Octatropine) bromide is an orally active anticholinergic muscarinic antagonist. Anisotropine bromide can inhibit gastric acid secretion and is used as an adjunct to peptic ulcers.
    Anisotropine bromide
  • HY-B1506
    Acepromazine 61-00-7 98%
    Acepromazine (Acetopromazine) is a phenothiazine tranquilizeran and alpha-adrenoceptor antagonist.
    Acepromazine
  • HY-B1740
    Pregnenolone acetate 1778-02-5 98.40%
    Pregnenolone acetate (compound #43), a nonmetabolized Pregnenolone (HY-B0151) analog, can promote neurite extension and induce a change in growth cone morphology in primary cultures of cerebellar granule neurons. Pregnenolone acetate, a neurosteroid, increases microtubule polymerization. Pregnenolone acetate has the potential for neurodevelopmental diseases research.
    Pregnenolone acetate
  • HY-B1755
    Risocaine 94-12-2 ≥98.0%
    Risocaine, also known as Propyl 4-aminobenzoate, with potential neuroleptic properties.
    Risocaine
  • HY-D1631
    Calcium Green-5N AM 216699-33-1
    Calcium Green-5N AM is a novel Ca2+-sensitive fluorescent probe. Calcium Green-5N AM shows enhancement in fluorescence intensity on binding Ca2+, and can monitor free Ca2+ in neurons.
    Calcium Green-5N AM
  • HY-N0307
    Ciwujianoside B 114902-16-8 99.00%
    Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory. Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of Bax/Bcl-2 in bone marrow cells exposed to radiation.
    Ciwujianoside B
  • HY-N0329
    Deltaline 6836-11-9 99.61%
    Deltaline is a diterpenoid alkaloid and isolated from plants of the genus Delphinium delavayi Franch. Deltaline itself has analgesic properties, and plants of the genus Delphinium delavayi Franch have also been therapeutically used to treat rheumaticpain, paralysis due to stroke, rheumatoid arthritis.
    Deltaline
  • HY-N0435
    Isorhamnetin 3-gentiobioside 17429-69-5 99.69%
    Isorhamnetin 3-gentiobioside protects the morphological structures and restores acetylcholine level in rat hippocampus, and improves brain functions via normalizing brain EEG.
    Isorhamnetin 3-gentiobioside
  • HY-N0495
    Aloenin 38412-46-3 99.91%
    Aloenin (Aloenin A) is a kind of natural product, has effective clearing and free radical activity, and has moderate inhibitory activity on β-secretion (BACE) (IC50=14.95 μg/mL). Aloenin suppresses peritoneal hypertrophy in large rats and suppresses its release.
    Aloenin
  • HY-N0801
    Polygalacic acid 22338-71-2 98.92%
    Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.
    Polygalacic acid
  • HY-N1100
    Vasicinone 486-64-6 99.89%
    Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders.
    Vasicinone
  • HY-N1163
    Tetrahydroalstonine 6474-90-4 ≥99.0%
    Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury.
    Tetrahydroalstonine
  • HY-N1276
    Secoisolariciresinol Monoglucoside 63320-67-2
    Secoisolariciresinol Monoglucoside is a natural product isolated from the seeds of Linum usitatissimum L..
    Secoisolariciresinol Monoglucoside
  • HY-N1978
    3'-Methoxypuerarin 117047-07-1 ≥99.0%
    3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.
    3'-Methoxypuerarin
  • HY-N2107
    Physion 8-O-β-D-glucoside 26296-54-8 ≥98.0%
    Physion 8-O-β-D-glucoside, a bioactive component of Fallopia multiflora, can be used for the research of dizziness.
    Physion 8-O-β-D-glucoside
  • HY-N2215
    Aloeresin D 105317-67-7 99.51%
    Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC50 of 39 μM.
    Aloeresin D
  • HY-N2530
    Notoginsenoside Fa 88100-04-3 ≥99.00%
    Notoginsenoside Fa, a protopanaxadiol (ppd)-type saponin isolated from P. notoginseng, could possibly activate and recover the function of degenerated brain.
    Notoginsenoside Fa
  • HY-N2612
    O-Methyldauricine 2202-17-7
    O-Methyldauricine ((-)-O-Methyldauricine) is an alkaloid with benzylisoquinoline group, which can be separated from P. ophthalmicus. O-Methyldauricine has antibacterial activity.
    O-Methyldauricine
Cat. No. Product Name / Synonyms Application Reactivity